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JAK3-IN-14

JAK3-IN-14 is a potent, selective, and orally bioavailable small molecule inhibitor of FLT3, demonstrating nanomolar IC50 values against FLT3-WT, FLT3-D835Y, and FLT3-D835H mutants. It is a valuable research tool for investigating FLT3-driven pathologies, such as acute myeloid leukemia (AML), in both cellular and animal models.

Product Specifications

CAS Number

454234-24-3

Product Name Alternative

(3Z) 5 (pyridin3yl) 3[ (1Hpyrrol2yl) methylidene]2,3dihydro1Hindol2one, FLT3, JAK3-IN-14

Field of Research

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Purity

98.29% (May vary between batches)

Solubility

DMSO:50 mg/mL (174.02 mM)

Smiles

C (=C1C=2C (NC1=O) =CC=C (C2) C=3C=CC=NC3) C4=CC=CN4

Molecular Formula

C18H13N3O

Molecular Weight

287.32

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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