JAK3-IN-14
JAK3-IN-14 is a potent, selective, and orally bioavailable small molecule inhibitor of FLT3, demonstrating nanomolar IC50 values against FLT3-WT, FLT3-D835Y, and FLT3-D835H mutants. It is a valuable research tool for investigating FLT3-driven pathologies, such as acute myeloid leukemia (AML), in both cellular and animal models.
Product Specifications
CAS Number
454234-24-3
Product Name Alternative
(3Z) 5 (pyridin3yl) 3[ (1Hpyrrol2yl) methylidene]2,3dihydro1Hindol2one, FLT3, JAK3-IN-14
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.29% (May vary between batches)
Solubility
DMSO:50 mg/mL (174.02 mM)
Smiles
C (=C1C=2C (NC1=O) =CC=C (C2) C=3C=CC=NC3) C4=CC=CN4
Molecular Formula
C18H13N3O
Molecular Weight
287.32
Storage Conditions
-20°C
Notes
For research use only.
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