AT-533
AT-533 is a dual Hsp90 and HSV inhibitor that suppresses tumor growth and angiogenesis by blocking the HIF-1α/VEGF/VEGFR-2 signaling axis and downstream pathways like Erk1/2 and Akt/mTOR. It has demonstrated anti-angiogenic activity in vitro by inhibiting HUVEC migration, invasion, and tube formation, supporting its research application in oncology and virology studies.
Product Specifications
CAS Number
908112-37-8
Product Name Alternative
AT533, AT-533, AT 533, Benzamide,2[ (trans4hydroxycyclohexyl) amino]4 (4,5,6,7tetrahydro3,6,6trimethyl4oxo1Hindazol1yl), HSV, HSP90
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Infectious Disease & Virology, Metabolism Research, Signal Transduction
Purity
99.54% (May vary between batches)
Solubility
DMSO:60 mg/mL (146.16 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.87 mM)
Smiles
Cc1nn (c2CC (C) (C) CC (=O) c12) -c1ccc (C (N) =O) c (N[C@H]2CC[C@H] (O) CC2) c1
Molecular Formula
C23H30N4O3
Molecular Weight
410.51
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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