GSK215
GSK215 is a potent and selective PROTAC degrader of focal adhesion kinase (FAK), achieving degradation with a pDC50 of 8.4. It is built from the FAK inhibitor VS-4718 and a VHL E3 ligase ligand, enabling rapid and sustained FAK loss, a valuable tool for studying FAK biology in cancer and metastasis research both in vitro and in vivo.
Product Specifications
CAS Number
2743427-26-9
Product Name Alternative
GSK 215, GSK215, GSK-215, FAK
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
99.30% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (5.08 mM) ; DMSO:225 mg/mL (228.4 mM)
Smiles
CNC (=O) c1ccccc1Nc1cc (Nc2ccc (cc2OC) N2CCN (CC (=O) N[C@H] (C (=O) N3C[C@H] (O) C[C@H]3C (=O) N[C@@H] (C) c3ccc (cc3) -c3scnc3C) C (C) (C) C) CC2) ncc1C (F) (F) F
Molecular Formula
C50H59F3N10O6S
Molecular Weight
985.13
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS2403093-01 0.06 mL
CLDN23/Claudin 23 Rabbit anti-Human Polyclonal Antibody
Sign In for Pricing
View Details MBS2403093-02 5x 0.06 mL
CLDN23/Claudin 23 Rabbit anti-Human Polyclonal Antibody
Sign In for Pricing
View Details 