TH1760
TH1760 (MKB) is a potent NUDT15 inhibitor (IC50=25 nM) that increases cellular 6-thio- (d) GTP incorporation, thereby sensitizing cells to 6-thioguanine. This compound enhances the anti-leukemic activity of thiopurines in research models, supporting its investigation in hematological malignancies.
Product Specifications
CAS Number
2567914-01-4
Product Name Alternative
TH1760, TH-1760, TH 1760, NUDIX hydrolase, NUDIXhydrolase, NUDT15, MKB
Field of Research
Cell Biology, Metabolism Research, Molecular Biology
Purity
97.03% (May vary between batches)
Solubility
DMSO:1.8 mg/mL (4.22 mM)
Smiles
S (=O) (=O) (C=1C=C2C (=CC1) NC (=O) O2) N3CCN (C (=O) C=4C=C5C (=CC4) NC=C5) CC3
Molecular Formula
C20H18N4O5S
Molecular Weight
426.45
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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