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TH1760

TH1760 (MKB) is a potent NUDT15 inhibitor (IC50=25 nM) that increases cellular 6-thio- (d) GTP incorporation, thereby sensitizing cells to 6-thioguanine. This compound enhances the anti-leukemic activity of thiopurines in research models, supporting its investigation in hematological malignancies.

Product Specifications

CAS Number

2567914-01-4

Product Name Alternative

TH1760, TH-1760, TH 1760, NUDIX hydrolase, NUDIXhydrolase, NUDT15, MKB

Field of Research

Cell Biology, Metabolism Research, Molecular Biology

Purity

97.03% (May vary between batches)

Solubility

DMSO:1.8 mg/mL (4.22 mM)

Smiles

S (=O) (=O) (C=1C=C2C (=CC1) NC (=O) O2) N3CCN (C (=O) C=4C=C5C (=CC4) NC=C5) CC3

Molecular Formula

C20H18N4O5S

Molecular Weight

426.45

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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