CPI-360
CPI-360 is a potent and selective small molecule inhibitor of EZH2, demonstrating sub-nanomolar enzymatic inhibition and cellular activity. It has shown antitumor efficacy in EZH2-dependent xenograft models, supporting its use as a chemical probe for epigenetic research in oncology, both in vitro and in vivo.
Product Specifications
CAS Number
1802175-06-9
Product Name Alternative
Synonym 2, Synonym 2, Histone Methyltransferase, HistoneMethyltransferase, EZH2, CPI 360, CPI360, CPI-360, Apoptosis
Field of Research
Cell Biology, Epigenetics & Chromatin
Purity
99.52% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMF:9 mg/mL (20.57 mM) ; Ethanol:27 mg/mL (61.71 mM) ; DMSO:22.5 mg/mL (51.43 mM)
Smiles
[C@H] (C) (N1C=2C (C (C (NCC3=C (OC) C=C (C) NC3=O) =O) =C1C) =CC=CC2) C4CCOCC4
Molecular Formula
C25H31N3O4
Molecular Weight
437.53
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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