Guanfu base A
Guanfu base A is a potent, noncompetitive inhibitor of the cytochrome P450 2D6 enzyme (CYP2D6) and also blocks the hERG potassium channel. This dual activity makes it a valuable pharmacological tool for investigating drug metabolism interactions and cardiac safety in both in vitro and in vivo research settings.
Product Specifications
CAS Number
1394-48-5
Product Name Alternative
Inhibit, KcsA, Guanfu base A, Guan-fu base A, Inhibitor, hERG, CYP2D6, PotassiumChannel, Potassium Channel
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
99.71% (May vary between batches)
Solubility
DMSO:10 mM;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.66 mM)
Smiles
[H][C@@]12CC34CC (=C) [C@]5 ([H]) [C@@H] (O) [C@@]3 ([H]) [C@@]36C[C@H] (C[C@@] (C) (CN1C3[C@@]4 (O) [C@@H]5OC (C) =O) [C@@]26[H]) OC (C) =O
Molecular Formula
C24H31NO6
Molecular Weight
429.5
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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