6-Diazo-5-oxo-L-nor-Leucine
6-Diazo-5-oxo-L-norleucine (DON) is a glutaminase inhibitor (Ki: ~6 μM) with antineoplastic properties, originally isolated from Streptomyces. It is widely used in cancer metabolism research to study glutamine dependency in vitro and has been evaluated in historical clinical trials for its antitumor effects in vivo.
Product Specifications
CAS Number
157-03-9
Product Name Alternative
6 Diazo 5 oxo L nor Leucine, 6Diazo5oxoLnorLeucine, 6-Diazo-5-oxo-L-nor-Leucine, Antibiotic, Bacterial, Diazooxonorleucine, DON, Glutaminase, Inhibitor, L-6-Diazo-5-oxonorleucine, inhibit, Influenza Virus, InfluenzaVirus
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry
Purity
98.04% (May vary between batches)
Solubility
H2O:12.5 mg/mL (73.04 mM) ; DMSO:7 mg/mL (40.9 mM)
Smiles
N[C@@H] (CCC (=O) C=[N+]=[N-]) C (O) =O
Molecular Formula
C6H9N3O3
Molecular Weight
171.15
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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