SYN1143
SYN1143 (AMG-1) is a highly potent small molecule inhibitor targeting the RON and c-Met receptor tyrosine kinases, exhibiting in vitro IC50 values of 9 nM and 4 nM, respectively. This compound is a valuable research tool for investigating cancer cell signaling, proliferation, and metastasis in both cellular and animal models of various malignancies.
Product Specifications
CAS Number
913376-84-8
Product Name Alternative
SYN 1143, SYN1143, SYN-1143, RON-IN-1, RON, tumor, inhibit, Inhibitor, HGFR, cancer, AMG 1, AMG1, AMG-1, c-Met/HGFR, cMet, c-Met, cMet/HGFR, dual
Field of Research
Signal Transduction
Purity
98.86% (May vary between batches)
Solubility
DMSO:90 mg/mL (161.7 mM)
Smiles
COc1ccc2c (Oc3ccc (NC (=O) c4c (C) n (CC (C) (C) O) n (-c5ccccc5) c4=O) cc3F) ccnc2c1
Molecular Formula
C31H29FN4O5
Molecular Weight
556.58
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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