β-Caryophyllene

β-Caryophyllene is a CB2 receptor agonist.

Product Specifications

CAS Number

[87-44-5]

Product Name Alternative

(-) - (E) -Caryophyllene; (−) -β-caryophyllene; (−) -trans-Caryophyllene

UNSPSC

12352211

Hazard Statement

H302, H413

Target

Cannabinoid Receptor; Endogenous Metabolite

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_beta_-Caryophyllene.html

Purity

99.75

Solubility

DMSO : 25 mg/mL (ultrasonic) |Ethanol : ≥ 176.67 mg/mL|H2O : < 0.1 mg/mL

Smiles

C=C1CC/C=C(C)/CC[C@@]2([H])C(C)(C)C[C@]12[H]

Molecular Formula

C15H24

Molecular Weight

204.35

Precautions

H302, H413

References & Citations

[1]Cheng Y, et al. β-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARγ pathway. Pharmacology. 2014;94 (1-2) :1-12.|[2]Dahham SS, et al. The Anticancer, Antioxidant and Antimicrobial Properties of the Sesquiterpene β-Caryophyllenefrom the Essential Oil of Aquilaria crassna. Molecules. 2015 Jun 26;20 (7) :11808-29.|[3]de Oliveira CC, et al. Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures. Epilepsy Behav. 2016 Mar;56:26-31.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

Phase 3

Isoform

Human Endogenous Metabolite

Citation 01

Int J Mol Sci. 2025 May 7;26 (9) :4430.|Neuropharmacology. 2025 Oct 28:283:110752.|Phytomedicine.|SSRN. 2025 Jun 13.|Metab Brain Dis. 2025 Oct 30;40 (8) :301.