β-Caryophyllene
β-Caryophyllene is a CB2 receptor agonist.
Product Specifications
CAS Number
87-44-5
Product Name Alternative
(-) - (E) -Caryophyllene; (−) -β-caryophyllene; (−) -trans-Caryophyllene
UNSPSC
12352211
Hazard Statement
H302, H413
Target
Cannabinoid Receptor; Endogenous Metabolite
Type
Natural Products
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_beta_-Caryophyllene.html
Purity
99.75
Solubility
DMSO : 25 mg/mL (ultrasonic) |Ethanol : ≥ 176.67 mg/mL|H2O : < 0.1 mg/mL
Smiles
C=C1CC/C=C(C)/CC[C@@]2([H])C(C)(C)C[C@]12[H]
Molecular Formula
C15H24
Molecular Weight
204.35
Precautions
H302, H413
References & Citations
[1]Cheng Y, et al. β-Caryophyllene ameliorates the Alzheimer-like phenotype in APP/PS1 Mice through CB2 receptor activation and the PPARγ pathway. Pharmacology. 2014;94 (1-2) :1-12.|[2]Dahham SS, et al. The Anticancer, Antioxidant and Antimicrobial Properties of the Sesquiterpene β-Caryophyllenefrom the Essential Oil of Aquilaria crassna. Molecules. 2015 Jun 26;20 (7) :11808-29.|[3]de Oliveira CC, et al. Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures. Epilepsy Behav. 2016 Mar;56:26-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 3
Isoform
Human Endogenous Metabolite
Citation 01
Int J Mol Sci. 2025 May 7;26 (9) :4430.|Neuropharmacology. 2025 Oct 28:283:110752.|Phytomedicine.|SSRN. 2025 Jun 13.|Metab Brain Dis. 2025 Oct 30;40 (8) :301.
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