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NBC 6

NLRP3-IN-NBC6 is a selective small molecule inhibitor of the NLRP3 inflammasome with an IC50 of 574 nM. It functions independently of calcium signaling and effectively blocks nigericin-induced activation in THP-1 cells and imiquimod-induced IL-1β release in primed BMDMs. This compound is a valuable research tool for investigating NLRP3-driven pathologies in both cellular and animal models.

Product Specifications

CAS Number

2068818-02-8

Field of Research

Immunology & Inflammation

Smiles

C (Cl) (Cl) (Cl) C1=[NH][B+3] (O=C (N) [C-]1C (C) =O) ([C-]=2C=CC=CC2) [C-]=3C=CC=CC3

Molecular Formula

C18H16BCl3N2O2

Molecular Weight

409.5

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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