NBC 6
NLRP3-IN-NBC6 is a selective small molecule inhibitor of the NLRP3 inflammasome with an IC50 of 574 nM. It functions independently of calcium signaling and effectively blocks nigericin-induced activation in THP-1 cells and imiquimod-induced IL-1β release in primed BMDMs. This compound is a valuable research tool for investigating NLRP3-driven pathologies in both cellular and animal models.
Product Specifications
CAS Number
2068818-02-8
Field of Research
Immunology & Inflammation
Smiles
C (Cl) (Cl) (Cl) C1=[NH][B+3] (O=C (N) [C-]1C (C) =O) ([C-]=2C=CC=CC2) [C-]=3C=CC=CC3
Molecular Formula
C18H16BCl3N2O2
Molecular Weight
409.5
Storage Conditions
-20°C
Notes
For research use only.
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