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AP-1/NF-κB activation inhibitor 1

This small molecule inhibitor potently suppresses AP-1 and NF-κB-driven transcriptional activation (IC50 ~1 μM) without affecting basal β-actin promoter activity. It effectively reduces pro-inflammatory cytokine production, such as IL-2 and IL-8, making it a valuable tool for studying inflammation and immune signaling pathways in cellular models.

Product Specifications

CAS Number

188936-12-1

Product Name Alternative

AP 1/NF κB activation inhibitor 1, AP-1/NF-kappaB activation inhibitor 1, AP-1/NF-kB activation inhibitor 1, AP1/NFκB activation inhibitor 1, AP-1/NF-κB activation inhibitor 1, AP-1, DNA Synthesis, DNASynthesis, NFkB, NFκB, NF-kB, NF-κB, RNASynthesis, RNA Synthesis

Field of Research

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Purity

99.52% (May vary between batches)

Solubility

DMSO:225 mg/mL (653.59 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.52 mM)

Smiles

CCOC (=O) c1cnc (nc1NN1C (=O) C=C (C) C1=O) C (F) (F) F

Molecular Formula

C13H11F3N4O4

Molecular Weight

344.25

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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