JAK-IN-14
JAK-IN-14 (compound 16) is a potent and selective JAK1 inhibitor (IC50 <5 μM) with over 8-fold selectivity against JAK2/JAK3. It functions by binding the JAK1 active site to inhibit its phosphorylation. This inhibitor is a valuable research tool for studying immune, inflammatory, and oncological pathways in both cellular and animal models.
Product Specifications
CAS Number
1973485-06-1
Product Name Alternative
JAK IN 14, JAK-IN-14, JAKIN14
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.27% (May vary between batches)
Solubility
DMSO:5 mg/mL (14.95 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.99 mM)
Smiles
N#CCC=1C=CC (=C (F) C1) C2=CC=CC3=NC (=CN32) NC (=O) C4CC4
Molecular Formula
C19H15FN4O
Molecular Weight
334.35
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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