MLS000532223
MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 values ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases[1].
Product Specifications
CAS Number
[16616-39-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mls000532223.html
Purity
98.45
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC([N+]([O-])=O)=C1)C#CC2=CC=CC=C2
Molecular Formula
C15H9NO3
Molecular Weight
251.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Zurab Surviladze, et al. Identification of a Small GTPase Inhibitor Using a High-Throughput Flow Cytometry Bead-Based Multiplex Assay. J Biomol Screen. 2010 Jan;15 (1) :10-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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