NVP-AEW541
NVP-AEW541 (AEW541) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC50 value of 0.15 μM. NVP-AEW541 also inhibits InsR, IC50 with a value of 0.14 μM. NVP-AEW541 has antitumor activity[1].
Product Specifications
CAS Number
475489-16-8
Product Name Alternative
AEW541
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Autophagy; IGF-1R; Insulin Receptor
Type
Reference compound
Related Pathways
Autophagy; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/NVP-AEW541.html
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
NC1=C2C(N([C@@H]3C[C@@H](C3)CN4CCC4)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1
Molecular Formula
C27H29N5O
Molecular Weight
439.55
Precautions
H315, H319
References & Citations
[1]García-Echeverría C, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004 Mar;5 (3) :231-9.|[2]Tanno B, et al. Down-regulation of IGF-1 receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo. Clin Cancer Res. 2006, 12 (22), 6772-6780.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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