NVP-AEW541

NVP-AEW541 (AEW541) is an orally active inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with an IC50 value of 0.15 μM. NVP-AEW541 also inhibits InsR, IC50 with a value of 0.14 μM. NVP-AEW541 has antitumor activity[1].

Product Specifications

CAS Number

[475489-16-8]

Product Name Alternative

AEW541

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Autophagy; IGF-1R; Insulin Receptor

Type

Reference compound

Related Pathways

Autophagy; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/NVP-AEW541.html

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

NC1=C2C(N([C@@H]3C[C@@H](C3)CN4CCC4)C=C2C5=CC=CC(OCC6=CC=CC=C6)=C5)=NC=N1

Molecular Formula

C27H29N5O

Molecular Weight

439.55

Precautions

H315, H319

References & Citations

[1]García-Echeverría C, et al. In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell. 2004 Mar;5 (3) :231-9.|[2]Tanno B, et al. Down-regulation of IGF-1 receptor activity by NVP-AEW541 has an antitumor effect on neuroblastoma cells in vitro and in vivo. Clin Cancer Res. 2006, 12 (22), 6772-6780.