5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone

This prenylated flavonoid exhibits potent anti-proliferative activity against ER-positive MCF-7 breast cancer cells in vitro (IC50 = 4.41 μM) by down-regulating ER-α expression. It has also demonstrated significant tumor growth inhibition in a BCAP-37 xenograft model, supporting its role as a candidate for research in oncology and hormone receptor signaling pathways.