Tarenflurbil
Product Specifications
UNSPSC Description
Tarenflurbil ((R)-Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R)-Flurbiprofen) inhibits the binding of [3H]9-cis-RA to RXRα LBD with IC50 of 75 μM. Tarenflurbil can be used for Alzheimer's disease research.
Target Antigen
Autophagy; RAR/RXR
Type
Reference compound
Related Pathways
Autophagy;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/_R_-Flurbiprofen.html
Purity
99.96
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(O)[C@H](C)C1=CC=C(C2=CC=CC=C2)C(F)=C1
Molecular Weight
244.26
References & Citations
[1]You X, et al. Retinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid. J Neurochem. 2009 Oct;111(1):142-9.|[2]Wanngren J, et al. Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production. J Biol Chem. 2012 Sep 21;287(39):32640-50.|[3]Schmitz K, et al. R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice. EMBO Mol Med. 2014 Sep 30;6(11):1398-422.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10291/Tarenflurbil-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10291/Tarenflurbil-SDS-MedChemExpress.pdf
Clinical Information
Phase 3
CAS Number
51543-40-9
Available Sizes
Curated Selection
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