Tarenflurbil

Tarenflurbil ((R) -Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R) -Flurbiprofen) inhibits the binding of [3H]9-cis-RA to RXRα LBD with IC50 of 75 μM. Tarenflurbil can be used for Alzheimer's disease research.

Product Specifications

CAS Number

[51543-40-9]

Product Name Alternative

(R) -Flurbiprofen; MPC7869

UNSPSC

12352005

Hazard Statement

H301+H311, H317, H361

Target

Autophagy; RAR/RXR

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/_R_-Flurbiprofen.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)[C@H](C)C1=CC=C(C2=CC=CC=C2)C(F)=C1

Molecular Formula

C15H13FO2

Molecular Weight

244.26

Precautions

H301+H311, H317, H361

References & Citations

[1]You X, et al. Retinoid X receptor-alpha mediates (R) -flurbiprofen's effect on the levels of Alzheimer's beta-amyloid. J Neurochem. 2009 Oct;111 (1) :142-9.|[2]Wanngren J, et al. Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production. J Biol Chem. 2012 Sep 21;287 (39) :32640-50.|[3]Schmitz K, et al. R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice. EMBO Mol Med. 2014 Sep 30;6 (11) :1398-422.