(S, R, S) -AHPC-PEG1-NH2

(S, R, S) -AHPC-PEG1-NH2 (VH032-PEG1-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology[1].

Product Specifications

CAS Number

[2241641-57-4]

Product Name Alternative

VH032-PEG1-NH2

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-r-s-ahpc-peg1-nh2.html

Purity

98.48

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCN)=O

Molecular Formula

C26H37N5O5S

Molecular Weight

531.67

Precautions

H302, H315, H319

References & Citations

[1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.