DC07090 (dihydrochloride)

DC07090 dihydrochloride is a low toxicity, potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC50 and a Ki value for 21.72 μM and 23.29 μM. DC07090 dihydrochloride could also inhibit coxsackievirus A16 (CVA16) replication with an EC50 value of 27.76 μM[1].

Product Specifications

CAS Number

[1158264-37-9]

UNSPSC

12352005

Target

Enterovirus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dc07090-dihydrochloride.html

Purity

99.12

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[H]Cl.[H]Cl.C1(CNC2=CC=C(C3=NC4=NC=CC=C4O3)C=C2)=NC=CC=C1

Molecular Formula

C18H16Cl2N4O

Molecular Weight

375.25

References & Citations

[1]Ma GH, et al. Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening. Eur J Med Chem. 2016 Nov 29;124:981-991.