DC07090 (dihydrochloride)
DC07090 dihydrochloride is a low toxicity, potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC50 and a Ki value for 21.72 μM and 23.29 μM. DC07090 dihydrochloride could also inhibit coxsackievirus A16 (CVA16) replication with an EC50 value of 27.76 μM[1].
Product Specifications
CAS Number
[1158264-37-9]
UNSPSC
12352005
Target
Enterovirus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dc07090-dihydrochloride.html
Purity
99.12
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[H]Cl.[H]Cl.C1(CNC2=CC=C(C3=NC4=NC=CC=C4O3)C=C2)=NC=CC=C1
Molecular Formula
C18H16Cl2N4O
Molecular Weight
375.25
References & Citations
[1]Ma GH, et al. Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening. Eur J Med Chem. 2016 Nov 29;124:981-991.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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