PF 04671536 hydrochloride
This orally bioavailable small molecule is a potent and selective inhibitor of PDE8B and PDE8A (IC50 ~1-2 nM), with high selectivity over other PDEs (>10 μM) . It enhances glucose-dependent insulin secretion in human pancreatic islet cells, making it a valuable research tool for studying cAMP signaling in diabetes and metabolic disorders.
Product Specifications
CAS Number
1305116-67-9
Field of Research
Metabolism Research
Smiles
Cl.Cc1nc (N) c2nnn (C[C@H]3CN (Cc4nccs4) CCO3) c2n1
Molecular Formula
C14H19ClN8OS
Molecular Weight
382.87
Storage Conditions
-20°C
Notes
For research use only.
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