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PF 04671536 hydrochloride

This orally bioavailable small molecule is a potent and selective inhibitor of PDE8B and PDE8A (IC50 ~1-2 nM), with high selectivity over other PDEs (>10 μM) . It enhances glucose-dependent insulin secretion in human pancreatic islet cells, making it a valuable research tool for studying cAMP signaling in diabetes and metabolic disorders.

Product Specifications

CAS Number

1305116-67-9

Field of Research

Metabolism Research

Smiles

Cl.Cc1nc (N) c2nnn (C[C@H]3CN (Cc4nccs4) CCO3) c2n1

Molecular Formula

C14H19ClN8OS

Molecular Weight

382.87

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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