Seco-DUBA
Seco-DUBA is a DNA alkylating prodrug and cytotoxic ADC payload with potent in vitro activity, exhibiting IC50 values of 18 nM in KB cells and 430 pM in SK-OV-3 cells. It is designed for enhanced in vivo stability, converting to the active DUBA metabolite for anticancer research applications.
Product Specifications
CAS Number
1227961-59-2
Product Name Alternative
ADCCytotoxin, ADC Cytotoxin, SecoDUBA, Seco-DUBA, Seco DUBA
Field of Research
Molecular Biology
Purity
99.81% (May vary between batches)
Solubility
DMSO:80 mg/mL (151.81 mM)
Smiles
C (Cl) [C@H]1C2=C (N (C (=O) C=3N=C4N (C3) C=C (NC (=O) C5=CC=C (O) C=C5) C=C4) C1) C=C (O) C=6C2=C (C) C=CC6
Molecular Formula
C29H23ClN4O4
Molecular Weight
526.97
Storage Conditions
-20°C
Notes
For research use only.
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