UC-514321
UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity[1].
Product Specifications
CAS Number
[299420-83-0]
UNSPSC
12352005
Target
Apoptosis; STAT; TET Protein
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/uc-514321.html
Purity
98.0
Solubility
DMSO : 25 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)
Smiles
OC1=C(C=C2OCOC2=C1)C(N3CCOCC3)C4=CC(C(C)(C)C)=C(C(C(C)(C)C)=C4)O
Molecular Formula
C26H35NO5
Molecular Weight
441.56
References & Citations
[1]Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8 (1) :2099.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3; STAT5; TET1
Available Sizes
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