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VCP/p97 inhibitor-1

VCP/p97 inhibitor-1 is a potent small molecule targeting the AAA+ ATPase VCP/p97 with an IC50 of 54.7 nM. It disrupts protein homeostasis by inhibiting the degradation of ubiquitinated misfolded proteins via the proteasome. This compound is a valuable research tool for studying UPS-related pathologies, including cancer and neurodegenerative diseases, in cellular and animal models.

Product Specifications

CAS Number

2630950-38-6

Field of Research

Pharmacology & Drug Discovery; Cell Biology, Protein Biochemistry

Smiles

Cc1cc2c (NS (C) (=O) =O) cccc2n1-c1nc2CCCc2c (NCc2cccc (c2) B (O) O) n1

Molecular Formula

C24H26BN5O4S

Molecular Weight

491.37

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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