XVA143
XVA143 is an α/β I-like allosteric antagonist that inhibits LFA-1-mediated firm adhesion while paradoxically enhancing cell rolling and adhesion under shear flow. This unique dual-function profile makes it a valuable research tool for studying integrin signaling and leukocyte trafficking in both in vitro flow assays and in vivo inflammation models.
Product Specifications
CAS Number
264275-77-6
Field of Research
Signal Transduction
Purity
99.94% (May vary between batches)
Smiles
C (NCC1=CC (O) =CC=C1) (=O) C2=CC (Cl) =C (C (N[C@@H] (CNC (=O) C3=CC (O) =CC (O) =C3) C (O) =O) =O) C (Cl) =C2
Molecular Formula
C25H21Cl2N3O8
Molecular Weight
562.36
Storage Conditions
-20°C
Notes
For research use only.
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