NLRP3/AIM2-IN-3
NLRP3/AIM2-IN-3 is a species-specific dual inflammasome inhibitor that potently blocks NLRP3 and AIM2-dependent pyroptosis by disrupting ASC oligomerization, exhibiting an IC50 of 0.077 μM in THP-1 macrophages. This compound is a valuable research tool for studying inflammasome biology and associated pathologies in cellular models.
Product Specifications
CAS Number
1787787-60-3
Product Name Alternative
AIMP2-DX2, AIM2, NLRP3
Field of Research
Cell Biology, Immunology & Inflammation, Immunology & Inflammation; Cell Biology, Signal Transduction
Purity
97.04% (May vary between batches)
Solubility
Methanol:45 mg/mL (168.99 mM) ; DMSO:225 mg/mL (844.94 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (12.39 mM)
Smiles
Oc1cccc (NC (=O) Cc2ccc3cc[nH]c3c2) c1
Molecular Formula
C16H14N2O2
Molecular Weight
266.29
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
IC8924T-100UG 100 µg
Human ROR alpha/NR1F1 Alexa Fluor 594 Antibody
Sign In for Pricing
View Details 
C2446-50R2 25 µg
CD105, Recombinant, Human, Fc Chimera (Endoglin, gp160, TGF beta1,3 Receptor, ENG, END, ORW, HHT1, ORW1, FLJ41744)
Sign In for Pricing
View Details 
MBS2170223-01 0.1 mL
Monoclonal Antibody to Cluster Of Differentiation 180 (CD180)
Sign In for Pricing
View Details MBS2170223-02 0.2 mL
Monoclonal Antibody to Cluster Of Differentiation 180 (CD180)
Sign In for Pricing
View Details MBS2170223-03 0.5 mL
Monoclonal Antibody to Cluster Of Differentiation 180 (CD180)
Sign In for Pricing
View Details