NLRP3/AIM2-IN-3
NLRP3/AIM2-IN-3 is a species-specific dual inflammasome inhibitor that potently blocks NLRP3 and AIM2-dependent pyroptosis by disrupting ASC oligomerization, exhibiting an IC50 of 0.077 μM in THP-1 macrophages. This compound is a valuable research tool for studying inflammasome biology and associated pathologies in cellular models.
Product Specifications
CAS Number
1787787-60-3
Product Name Alternative
AIMP2-DX2, AIM2, NLRP3
Field of Research
Cell Biology, Immunology & Inflammation, Immunology & Inflammation; Cell Biology, Signal Transduction
Purity
97.04% (May vary between batches)
Solubility
Methanol:45 mg/mL (168.99 mM) ; DMSO:225 mg/mL (844.94 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (12.39 mM)
Smiles
Oc1cccc (NC (=O) Cc2ccc3cc[nH]c3c2) c1
Molecular Formula
C16H14N2O2
Molecular Weight
266.29
Storage Conditions
-20°C
Notes
For research use only.
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