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JH295 hydrate

JH295 hydrate is a potent, selective, and irreversible Nek2 inhibitor that acts via alkylation of Cys22 (IC50 = 770 nM) . It exhibits high selectivity, showing no activity against Cdk1, Aurora B, or Plk1, and does not disrupt spindle assembly or checkpoint function, making it a valuable chemical probe for studying Nek2's role in cancer and cell cycle research.

Product Specifications

Field of Research

Signal Transduction

Molecular Formula

C18H18N4O3

Molecular Weight

338.36

Storage Conditions

-20°C

Notes

For research use only.

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