Cdc7-IN-18
Cdc7-IN-18 is a potent and selective CDC7/DBF4 kinase inhibitor with an IC50 of 1.29 nM. It demonstrates robust antiproliferative activity in COLO205 cells (IC50 = 53.62 nM), making it a valuable chemical probe for researching DNA replication and cell cycle mechanisms in cancer models.
Product Specifications
CAS Number
2562329-14-8
Field of Research
Cell Biology, Signal Transduction
Smiles
O=C1C2=C (C3=C (S2) C=4C (CCC3) =NNC4) NC (=N1) [C@@H]5N6CCC (C5) CC6
Molecular Formula
C19H21N5OS
Molecular Weight
367.47
Storage Conditions
-20°C
Notes
For research use only.
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032329-AP 200 µL
Aurora-B, NT (AURKB, AIK2, AIM1, AIRK2, ARK2, STK1, STK12, STK5, Aurora kinase B, Aurora 1, Aurora- and IPL1-like midbody-associated protein 1, Aurora/IPL1-related kinase 2, STK-1, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 5, Serine/threonine-protein kinase aurora-B) (AP) discontinued
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