PD-1/PD-L1-IN-14

PD-1/PD-L1-IN-14 (compound 17) is a small molecule inhibitor that blocks PD-1/PD-L1 binding with an IC50 of 27.8 nM, leading to PD-L1 dimerization, internalization, and degradation. It is used in cancer immunotherapy research, including in vitro cellular assays and in vivo animal models for studying antitumor immune responses.