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EGFR-IN-49

EGFR-IN-49 is a selective small molecule inhibitor targeting EGFR T790M and T790M/L858R mutants with IC50 values of 65.0 nM and 13.6 nM, respectively. It induces dose-dependent apoptosis and is a useful tool compound for in vitro and in vivo studies of non-small cell lung cancer resistance mechanisms.

Product Specifications

CAS Number

2459932-81-9

Field of Research

Cardiovascular Research, Cell Biology, Signal Transduction

Smiles

O (C1=C2C (=NC (NC3=CC (C#N) =CC=C3) =N1) C=CS2) C4=CC (NC (C=C) =O) =CC=C4

Molecular Formula

C22H15N5O2S

Molecular Weight

413.45

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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