SKLB-197
SKLB-197 is a highly selective ATR inhibitor (IC50: 0.013 μM) with minimal activity against 402 other kinases. It demonstrates potent antitumor efficacy in both in vitro and in vivo models, particularly against ATM-deficient tumors, making it a valuable tool for oncology research targeting DNA damage response pathways.
Product Specifications
CAS Number
2713577-16-1
Field of Research
Molecular Biology, Signal Transduction
Purity
99.53% (May vary between batches)
Smiles
C[C@H]1N (C=2C3=C (N=C (N2) C4=C5C (NC=C5) =CC=C4) C=CC (=C3) C=6N (C) N=CC6) CCOC1
Molecular Formula
C25H24N6O
Molecular Weight
424.5
Storage Conditions
-20°C
Notes
For research use only.
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