Antifungal agent 22

Antifungal agent 22 (D16) is an orally bioavailable, brain-penetrant compound with selective activity against Cryptococcus neoformans. It exhibits fungicidal effects by compromising fungal cell membrane integrity, demonstrating good metabolic stability and low cytotoxicity in research models. This profile supports its investigation for treating cryptococcal infections in both in vitro and in vivo studies.