TPB15
TPB15 is an orally bioavailable small molecule inhibitor of Hedgehog signaling that acts by blocking Smoothened ciliary translocation and reducing its expression. It demonstrates potent anti-proliferative and pro-apoptotic activity in vitro, such as in MDA-MB-468 cells, and shows promising in vivo anti-tumor efficacy with a favorable toxicity profile.
Product Specifications
CAS Number
2170347-69-8
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Smiles
ClC=1C (C=2N3C (=NN2) C (Cl) =CC=C3) =CC (NC (=O) C4=C (Cl) N=C (Cl) C=C4) =CC1
Molecular Formula
C18H9Cl4N5O
Molecular Weight
453.11
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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