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TM-1

TM-1 is a cell-permeable PDHK inhibitor with IC50 values of 2.97 μM and 5.2 μM against PDHK1 and PDHK2, respectively. It activates the pyruvate dehydrogenase complex by blocking its phosphorylation and has been shown to suppress cancer cell proliferation in vitro, making it a useful tool for studying cancer metabolism.

Product Specifications

CAS Number

921099-13-0

Field of Research

Cell Biology, Metabolism Research, Protein Biochemistry

Purity

99.61% (May vary between batches)

Smiles

O=C1OC2=CC (OCCN3CCN (CCO) CC3) =CC=C2C (=C1C=4C=CC (OC) =C (OC) C4) C

Molecular Formula

C26H32N2O6

Molecular Weight

468.54

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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