LRRK2-IN-5
LRRK2-IN-5 is a brain-penetrant, orally bioavailable small molecule inhibitor of LRRK2 kinase, demonstrating selectivity with IC50 values of 1.2 μM and 16 μM for the GS and wild-type variants, respectively. It effectively reduces LRRK2 autophosphorylation at Ser1292 and Ser925, making it a valuable tool for investigating LRRK2 biology in cellular and in vivo models of Parkinson's disease.
Product Specifications
Field of Research
Cell Biology
Molecular Formula
C24H26F2N4O2S
Molecular Weight
472.55
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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