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LRRK2-IN-5

LRRK2-IN-5 is a brain-penetrant, orally bioavailable small molecule inhibitor of LRRK2 kinase, demonstrating selectivity with IC50 values of 1.2 μM and 16 μM for the GS and wild-type variants, respectively. It effectively reduces LRRK2 autophosphorylation at Ser1292 and Ser925, making it a valuable tool for investigating LRRK2 biology in cellular and in vivo models of Parkinson's disease.

Product Specifications

Field of Research

Cell Biology

Molecular Formula

C24H26F2N4O2S

Molecular Weight

472.55

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

Frequently Asked Questions

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