CFI-400437
CFI-400437 is a potent and selective ATP-competitive inhibitor of Polo-like kinase 4 (PLK4), with an IC50 of 0.6 nM. This indolequinone derivative is a valuable chemical probe for studying centriole duplication in cellular models and has demonstrated antitumor activity in preclinical in vivo studies.
Product Specifications
CAS Number
1169211-37-3
Field of Research
Cell Biology, Immunology & Inflammation
Smiles
C (=C/1\C=2C (NC1=O) =CC=C (OC) C2) \C=3C=C4C (=CC3) C (/C=C/C=5C=CC (=NC5) N6CCN (C) CC6) =NN4
Molecular Formula
C29H28N6O2
Molecular Weight
492.57
Storage Conditions
-20°C
Notes
For research use only.
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