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CFI-400437

CFI-400437 is a potent and selective ATP-competitive inhibitor of Polo-like kinase 4 (PLK4), with an IC50 of 0.6 nM. This indolequinone derivative is a valuable chemical probe for studying centriole duplication in cellular models and has demonstrated antitumor activity in preclinical in vivo studies.

Product Specifications

CAS Number

1169211-37-3

Field of Research

Cell Biology, Immunology & Inflammation

Smiles

C (=C/1\C=2C (NC1=O) =CC=C (OC) C2) \C=3C=C4C (=CC3) C (/C=C/C=5C=CC (=NC5) N6CCN (C) CC6) =NN4

Molecular Formula

C29H28N6O2

Molecular Weight

492.57

Storage Conditions

-20°C

Notes

For research use only.

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