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BRD4 Inhibitor-18

BRD4 Inhibitor-18 is a potent small molecule (IC50 = 110 nM) featuring a hydrophobic acetylcyclopentane moiety. It effectively suppresses proliferation in BRD4-high leukemia cells like MV-4-11 by inducing cell cycle arrest in G0/G1 phase and promoting apoptosis, making it a valuable tool for epigenetic and cancer research.

Product Specifications

CAS Number

2451219-73-9

Field of Research

Cell Biology, Epigenetics & Chromatin, Epigenetics & Chromatin; Pharmacology & Drug Discovery

Smiles

CN1C=2C=3C (C (=NC (CC (NC4CCCC4) =O) C2SC1=O) C5=CC=C (Cl) C=C5) =CC (OC) =CC3

Molecular Formula

C26H26ClN3O3S

Molecular Weight

496.02

Storage Conditions

-20°C

Notes

For research use only.

Available Sizes

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