PROTAC CDK12/13 Degrader-1

PROTAC CDK12/13 Degrader-1 (7f) is a highly potent and selective small molecule that induces the degradation of CDK12 and CDK13 with DC50 values in the low nanomolar range. This compound serves as a valuable chemical probe for investigating the roles of these kinases in transcription regulation and cell cycle control, particularly in breast cancer research models.