Flavopiridol
Flavopiridol (Alvocidib) is a potent ATP-competitive inhibitor of cyclin-dependent kinases CDK1, CDK2, CDK4, and CDK6 (IC50 ~40 nM), demonstrating selectivity over CDK7. It has been investigated in preclinical and clinical studies (Phase 1/2) for oncology research, showing activity in both in vitro cell proliferation assays and in vivo tumor models.
Product Specifications
CAS Number
146426-40-6
Product Name Alternative
Alvocidib, Apoptosis, Autophagy, CDK6, CDK7, CDK4, CDK, CDK1, CDK2, Cyclin dependent kinase, HIV, HIV Protease, HIVProtease, HMR 1275, HMR1275, HMR-1275, L868275, L-868275, L86-8275, Inhibitor, Human immunodeficiency virus, Flavopiridol, inhibit, NSC 649890 HCl, L 868275
Field of Research
Cell Biology, Infectious Disease & Virology, Protein Biochemistry
Purity
97.74% (May vary between batches)
Solubility
DMSO:34 mg/mL (84.61 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.98 mM) ; Ethanol:8 mg/mL (19.91 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CN1CC[C@@H] ([C@H] (O) C1) c1c (O) cc (O) c2c1oc (cc2=O) -c1ccccc1Cl
Molecular Formula
C21H20ClNO5
Molecular Weight
401.84
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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