H-1152
H-1152 is a potent and cell-permeable ROCK inhibitor with a Ki of 1.6 nM. It promotes neurite outgrowth in cultured neurons and blocks LPA-induced MARCKS phosphorylation at Ser159. This compound is widely used in neuroscience research to investigate Rho/ROCK signaling pathways in neuronal development, axon guidance, and regeneration models both in vitro and in vivo.
Product Specifications
CAS Number
451462-58-1
Product Name Alternative
Inhibit, Inhibitor, H 1152, H1152, H-1152, ROK, ROCK, Rho-associated kinase, Rho-associated protein kinase, Rho-kinase
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Solubility
DMSO:80 mg/mL (250.45 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (10.33 mM)
Smiles
S (=O) (=O) (C=1C2=C (C=CC1) C=NC=C2C) N3[C@@H] (C) CNCCC3
Molecular Formula
C16H21N3O2S
Molecular Weight
319.42
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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