CK2/ERK8-IN-1
CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 μM) and ERK8 (MAPK15, ERK7) inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 μM, 15.25 μM, and 11.9 μM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy[1].
Product Specifications
CAS Number
[1085822-09-8]
UNSPSC
12352005
Target
Apoptosis; Casein Kinase; DYRK; ERK; Pim
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ck2-erk8-in-1.html
Concentration
10mM
Purity
99.0
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=C(O)CN1C2=C(Br)C(Br)=C(Br)C(Br)=C2N=C1N(C)C
Molecular Formula
C11H9Br4N3O2
Molecular Weight
534.82
References & Citations
[1]Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415 (3) :353-65.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK2; DYRK1; ERK8; PIM1
Available Sizes
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