Isoangustone A
Isoangustone A is a cell-permeable natural product that acts as an ATP-competitive inhibitor of PI3K, MKK4, and MKK7. It suppresses G1/S phase progression and Akt/GSK-3β/JNK signaling, demonstrating anti-proliferative effects in human melanoma cells in vitro and reducing tumor growth in mouse xenograft models in vivo.
Product Specifications
CAS Number
129280-34-8
Product Name Alternative
NFκB, NF-κB, NFkB, NF-kB, MMP, Isoangustone A, JNK, GSK3, GSK-3, Akt, CDK, TGF-β/Smad, ROS, PI3K
Field of Research
Cell Biology, Signal Transduction
Purity
98.89% (May vary between batches)
Smiles
O=C1C (=COC2=CC (O) =C (C (O) =C12) CC=C (C) C) C=3C=C (O) C (O) =C (C3) CC=C (C) C
Molecular Formula
C25H26O6
Molecular Weight
422.47
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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