Rabbit anti Human Calcium Channel

Product Specifications

Background

Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omega-agatoxin-IVA (omega-aga-IVA).

CAS Number

9007-83-4

Synonyms

Voltage-Dependent L-Type Calcium Channel, β1 subunit

UniProt

Q02641

Host

Rabbit

Species Reactivity

Human

Isotype

IgG

Conjugation

Unconjugated

Type

Polyclonal Antibody

Applications

Field of Research

Signal Transduction

Purification Method

Ammonium Sulfate Precipitation

Assay Principle

This antibody can be used for Western blotting (5-10 µg/mL). Optimal concentration should be evaluated by serial dilutions.

Stability

See expiration date on vial

Concentration

See vial for Concentration

Form

Provided as solution in phosphate buffered saline with 0,08% sodium azide

Precautions

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

References & Citations

1. Powers, P.A., et al. 'Skeletal muscle and brain isoforms of a beta-subunit of Human voltage-dependent calcium channels are encoded by a single gene.' J. Biol. Chem. 1992, 267, 22967-22972. 2. Collin, T., et al. 'Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit form normal Human heart.' Circ. Res. 1993, 72, 1337-1344. 3. Fukuda, K., et al. 'Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes.' Neurosci. Lett. 1996, 217, 13-16. 4. Hogan, K., et al. 'Structure and alternative splicing of the gene encoding the Human beta1 subunit of voltage dependent calcium channels.' Neurosci. Lett. 1999, 277, 111-114.